Boban Tedić will make his full league debut as the Addicks host Exeter City at The Valley this evening.
Chuks Aneke, Ashley Maynard-Brewer and Louie Watson also start as Michael Appleton makes four changes from the team that drew with Shrewsbury Town at the weekend.
Tyreece Campbell and Miles Leaburn move to the bench while Terry Taylor is missing with the ankle injury that forced him off the pitch on Saturday. Harry Isted is set to miss around six weeks with a knee injury which he picked up and battled through towards the end of his EFL Team of the Week performance on Saturday.
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It means the Addicks may use the 4-2-3-1 formation played on Saturday with Tennai Watson, Michael Hector, Lloyd Jones and Terell Thomas in a back four in front of Maynard-Brewer.
In that formation Louie Watson would join skipper George Dobson in central midfield behind Tedić, Alfie May and Corey Blackett-Taylor, who will all support central forward Chuks Aneke.
Tyreece Campbell and Leaburn are joined on the bench by Henry Molyneux, Nathan Asiimwe, Lucas Ness, Scott Fraser and Chem Campbell.
Charlton: Maynard-Brewer; T Watson, Hector, Jones, Thomas; L Watson, Dobson (C); Tedić, May, Blackett-Taylor; Aneke
Subs: Molyneux, Asiimwe, Ness, Fraser, C Campbell, T Campbell, Leaburn