Conor McGrandles and Scott Fraser will both start this afternoon's match against Carlisle United at Brunton Park.
The duo come in for Louie Watson and Tyreece Campbell, who move to the bench, as Michael Appleton makes two changes from the Addicks' last league outing at Portsmouth a fortnight ago.
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The Addicks are expected to line-up in a 4-3-3 formation with Tennai Watson, Michael Hector, Lloyd Jones and Tayo Edun starting in a back four in front of goalkeeper Ashley Maynard-Brewer.
McGrandles and Fraser join captain George Dobson in midfield, behind a front three of Alfie May, Miles Leaburn and Corey Blackett-Taylor.
Louie Watson and Tyreece Campbell are joined on the bench by Sam Walker, Nathan Asiimwe, Lucas Ness, Terell Thomas and Slobodan Tedić.
Charlton: Maynard-Brewer; T.Watson, Hector, Jones, Edun; Dobson (c), McGrandles, Fraser; May, Leaburn, Blackett-Taylor
Substitutes: Walker, Asiimwe, Ness, Thomas, L.Watson, T.Campbell, Tedić