Ben Watson, Darren Pratley, Andrew Shinnie and Conor Washington return to the side with Lee Bowyer making four changes from the team that beat Northampton Town on Saturday for tonight's game against Oxford United.
Chuks Aneke returns to the bench after missing the game with a groin injury but Alfie Doughty is out after limping off against the Cobblers.
If the Addicks line-up in a 4-3-3, as they did on Saturday, it would mean Chris Gunter, Ryan Inniss, Akin Famewo and Ian Maatsen playing as a back four in front of Ben Amos.
In that formation Pratley, Watson and Shinnie would likely play in midfield behind a front three of Washington, Omar Bogle and Paul Smyth.
Jake Forster-Caskey, Jonny Williams and Dylan Levitt move to the bench, where they are joined by Ben Purrington, returning from suspension, Marcus Maddison, Ashley Maynard-Brewer and the aforementioned Aneke.
Charlton: Amos; Gunter, Inniss, Famewo, Maatsen; Pratley (C), Watson, Shinnie; Washington, Bogle, Smyth
Substitutes: Maynard-Brewer, Purrington, Forster-Caskey, Williams, Levitt, Maddison, Aneke