Academy starlet Deji Elerewe will make his full league debut in this afternoon's game against Oxford United.
Harry Isted comes in for his first league start, following his move to the Addicks this summer, and Lucas Ness returns as Dean Holden makes three changes to his side.
Ashley Maynard-Brewer, Michael Hector and Terry Taylor all move to the bench where they are joined by the returning Tyreece Campbell and new signing Chem Campbell.
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It means the Addicks are expected to line-up in a 3-5-2 formation with Elerewe and Ness joining Lloyd Jones in a back three ahead of Isted.
Nathan Asiimwe and Corey Blackett-Taylor will operate as wing backs with Tayo Edun expected to move into midfield alongside Karoy Anderson and skipper George Dobson.
Last weekend’s goalscorers, Alfie May and Daniel Kanu, once again start up front.
Terell Thomas and Jack Payne join Maynard-Brewer, Hector, Taylor and both Campbells on the bench.
Charlton: Isted; Elerewe, Ness, Jones; Asiimwe, Anderson, Dobson (c), Edun, Blackett-Taylor; May, Kanu
Substitutes: Maynard-Brewer, Hector, Thomas, Taylor, Payne, T Campbell, C Campbell