England U20 internationals Ezri Konsa and Jay Dasilva will replace Anfernee Dijksteel and Lewis Page at full back.
Dijksteel drops to the bench while Page is not in the squad as Bowyer looks to manage the minutes of the in-form left back.
You can listen to the game live on Valley Pass from 2.45pm and Page will be joining regular commentators Terry Smith and Greg Stubley in the commentary box.
Charlton: Amos, Konsa, Bauer, Pearce (c), Dasilva, Reeves, Aribo, Forster-Caskey, Fosu, Zyro, Ajose
Substitutes: Phillips, Sarr, Dijksteel, Marshall, Kaikai, Mavididi, Magennis