The Addicks' final match of the season will see them looking to book their place in the Championship for next season as they take on crowned champions Leeds United at Elland Road (7.30pm).
After securing a vital point against Wigan Athletic on Saturday, Lee Bowyer knows that his team's destiny is within their hands as they will search for three points which will see them safe no matter what come full-time.
A victory for Charlton would see them clear keep of the drop zone and even if Luton Town can also pick up a win at home to Blackburn Rovers, they would still finish below the Addicks, unless they make up an 18-goal difference.
Wigan Athletic's pending points deduction must also be taken into account and they have to beat promotion-chasing Fulham to stand a chase of leap-frogging Charlton in the table. Their 12-point deduction will be reflected on the final table come full-time.
A draw for the Addicks should be enough should Wigan fail to win, owing to a substantially better goal-difference than Barnsley. The Tykes would have to produce a 10-goal victory. Likewise, Hull City can still draw level on points, but would need a victory of 16 goals.
Should Wigan gain victory, however, the Addicks will still be safe as long as Luton fail to beat Blackburn, but victories for both Wigan and Luton, coupled with a Charlton draw will mean relegation.
It remains possible for the Addicks to survive even if they lose at Elland Road. Defeats for all involved would, of course, see Charlton safe. If Barnsley and Wigan both fail to win, it will also mean safety for the Addicks. A combination of two defeats from Barnsley, Wigan and Luton will also seal safety.
Ultimately, all this does, of course, depend on the eventual outcome of Wigan's appeal for their 12-point deduction for entering administration.
Marcelo Bielsa's men, meanwhile, do not appear to be resting on their laurels after winning the Championship having beaten Derby County 3-1 in their last outing and will lift the Championship trophy at the end of the evening.
Charlton will continue to miss Darren Pratley who was confirmed to be out through injury for the rest in of the campaign having picked up an injury at Birmingham City last week.
Elsewhere, fellow midfielders Jake Forster-Caskey and Sam Field both face a race against fitness to be considered ahead of the game with a tight groin and a bruised hip respectively.
Josh Cullen also sustained a knock but is expected to be okay for the final-day clash.
For Leeds, Gaetano Berardi is set for scans having been forced off with a knee injury in their game against Derby, while skipper Kalvin Phillips will be missing through injury.
Charlton Boss Lee Bowyer: “We’re in a good place. We need that bit of luck in front of goal and we’ll keep fighting. Since the lockdown, it’s been about pulling people together. We were in the bottom three and we’ve turned it around so it’s a credit to everyone at the club.I’m proud to stand in front of them.
“We have a tough game, but so do the teams around us. There will be some twists and turns on the night, that will happen, we just have to stay calm and believe that what we do on the night will keep us in the division."
Leeds boss Marcelo Bielsa: "We want to keep our standard and show we're the best team in the league, and that goes on until Wednesday."
The Addicks and the Whites have faced off 56 times in the past with Charlton emerging victorious on 20 occasions while Leeds have won 25 times. There have been 11 draws between the two sides.
The reverse fixture at The Valley saw Macauley Bonne score the only goal of the game as the Londoners took all the points back in September.
Charlton are unbeaten in their last eight trips to Elland Road, last tasting defeat in 2000.
The Addicks last visit saw them run out winners as Johann Berg Gudmundsson and Ademola Lookman found the scoresheet to ensure that Sol Bamba's strike was nothing more than a consolation.
Geoff Eltringham will be the man in the middle of the park on Wednesday night. He has produced 98 yellows and two red cards in 29 games this season.
This will be the second time he has officiated a Charlton game this season having overseen the defeat at Huddersfield Town back in February.
All of the remaining games of the 2019/20 season are being played behind closed doors and supporters are reminded to maintain social distancing guidelines and to stay away from stadiums when matches are taking place.
Supporters can follow all the build-up to the game on Charlton's official Instagram account, official Twitter account and Facebook page as usual. Supporters both in the UK and abroad are able to watch the game live on Valley Pass which includes a multi-camera broadcast, action replays and commentary from Terry Smith and Greg Stubley, the club's in-house commentary team.
Supporters who live abroad will be able to watch the game for the usual price of £5, while supporters in the UK and Ireland can purchase a game pass for £10 which is the minimum the club are allowed to charge due to EFL regulations.
Supporters who have already purchased a multi-game package will have been sent a code to access Wednesday's game.
Meanwhile, live audio commentary of the game from Smith and Stubley will be available to Valley Pass subscribers in all countries as usual.