Rarmani Edmonds-Green and Macaulay Gillesphey will make their full debuts for the Addicks against Northampton Town tonight.
The pair come into the starting line-up in place of Lucas Ness and Terell Thomas, who move to the bench.
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Edmonds-Green and Gillesphey are expected to join Lloyd Jones in a back three in front of Ashley Maynard-Brewer.
Tennai Watson and Tayo Edun are likely to operate as wing-backs either side of a midfield trio of Conor Coventry, captain George Dobson and Tyreeq Bakinson, with Freddie Ladapo partnering by Alfie May up front.
Ness and Thomas are joined on the bench by Harry Isted, Louie Watson, Lewis Fiorini Tyreece Campbell and Daniel Kanu.
Charlton: Maynard-Brewer; Edmonds-Green, Jones, Gillesphey; T.Watson, Coventry, Dobson (c), Bakinson, Edun; May, Ladapo
Subs: Isted, Ness, Thomas, L.Watson, Fiorini, Campbell, Kanu