Charlton will be hoping to go one better than Saturday's draw on Tuesday night when they take on Luton Town at Kenilworth Road.
Injuries continue to hamper the Addicks and Saturday saw them storm into two-goal lead and save a penalty before Cardiff City fought back and snatched a point.
The Hatters come into the game off the back of a 2-1 loss to Leeds United at the weekend and currently sit 22nd in the table, in the relegation zone on goal difference.
Josh Cullen was added to Charlton's long injury list on Saturday afternoon when he was stretchered off in the second half.
Bowyer's selection headache will no doubt only be worsened by the loss of the midfielder and he may opt to look to Charlton's young talent to fill the bench once again with Albie Morgan and Alfie Doughty likely to feature again.
Elsewhere, fellow midfielder Erhun Oztumer and defender Deji Oshilaja are also feeling the effects from the 2-2 draw with Cardiff while it was also revealed that Beram Kayal returned from international duty with a knock.
Tuesday will likely come too soon for Lyle Taylor, while Jake Forster-Caskey also remains sidelined alongside Ben Amos, Tomer Hemed, Jonny Williams and Sam Field.
For the Hatters, Martin Cranie could return for the fixture having missed their last fixture and Danny Hylton is back training but is unlikely to feature.
Charlton boss Lee Bowyer: “We’re going into Tuesday’s game and I honestly don’t know how many people are going to be fit to start.
"Senior players, I honestly don’t know. It ain’t looking good in the dressing room. Oztumer, he looks like he’s hurt. Josh is obviously hurt. Oshilaja was cramping up. There’s three just off the top of my head.”
Luton boss Graeme Jones: “I have challenged the players for the same level of performance, so I want that first and foremost, so if we get that, then we will get a result. It’s about standards, no two games in the Championship are the same.
So the challenge is to repeat what we did at the weekend in every area and if we do that, we will get a result.”
Charlton have faced Luton 73 times, winning on 26 occasions, losing on 33 and drawing 14 times.
The Addicks last took on Luton at The Valley in League One last season earning a brilliant 3-1 victory over the league leaders as Lee Bowyer's men surged towards the play-offs in fine form.
The last time we made the trip to Kenilworth Road, Charlton found themselves behind after a late surge from Luton saw them 2-1 up with 10 minutes to play.
With the game deep in to stoppage time, The Addicks snatched a draw from an unlikely source when Chris Solly drilled in the equaliser to snatch a point.
Darren England will be overseeing proceedings on Tuesday night. England has overseen eight Championship games this season, handing out 24 yellow cards and awarding two penalties. The last time he took control of a Charlton game was back in December 2016 when the Addicks played out a 0-0 stalemate with MK Dons in the FA Cup.
He will be joined by assistants Steven Meredith and Nick Greenhalgh with Andy Davies as the Fourth Official.
The Addicks will be cheered on by 1,032 supporters in a sold out away end.
Supporters who were unable to obtain tickets for the fixture can follow all the action through the club’s usual channels, including live commentary on Valley Pass.
Supporters can follow all the build-up to the game on Charlton's official Instagram account, official Twitter account and Facebook page.
Live commentary of the clash - presented by ITRM - will be available on Valley Pass exclusively for subscribers. Please click here for more information on how you can subscribe to Valley Pass and how you can purchase a 48-hour matchday pass, which is priced at just £4.