Charlton return to home turf as they host Doncaster Rovers at The Valley on Saturday with 1,000 Addicks set to be in attendance (3pm).
After six long months, it will be the first opportunity for supporters to get back into The Valley to back Bowyer's boys and they will be hoping to see a similar result to that of last weekend's season opener at Crewe Alexandra in which Charlton kicked of the campaign with three points.
Doncaster, meanwhile, got their first point on the board with a 1-1 draw at home to Milton Keynes Dons - an 88th-minute Dons equaliser cancelling out Madger Gomes' opener.
There are no fresh concerns for Bowyer on the injury front following Tuesday's cup clash with West Ham United.
Jason Pearce remains sidelined with a knee injury.
Charlton boss Lee Bowyer: "We know all about Doncaster from that play-off semi-final, so this fixture will bring back good memories of that night.
"They're a good side with good players that can hurt you, so we know we'll have to be at it. We just have to build on what we started at Crewe last week."
Doncaster boss Darren Moore: “We know it's going to be a tough game. They're a good team, we all know they've dropped down from the Championship so they have some wonderful individual players. They're a strong team in the division so we have to go and do our utmost at The Valley."
Charlton and Doncaster have met on 15 previous occasions, with the Addicks winning eight, Doncaster five (which includes the play-off semi-final second leg in 2019) and the remaining two ending in draws.
The last time the sides came face-to-face was, of course, that epic encounter back in May 2019 which saw the Addicks book their place at Wembley.
John Busby will be the man in the middle for Saturday's match in SE7. Last season, he oversaw a total of 33 games, producing 123 yellow cards and five red.
He last took charge of the Addicks for the Carabao Cup meeting with Forest Green Rovers at The Valley last term.
Fans may remember him from his last experience refereeing Charlton in a league fixture - the 1-0 win over Accrington Stanley which saw Lyle Taylor controversially sent-off alongside Stanley goalkeeper Jonny Maxted, before awarding the Addicks a match-winning penalty in injury time.
1,000 Charlton fans are able to attend the match at The Valley. Those without tickets are urged to stay away from the stadium to help ensure that the club will be able to facilitate more supporters at games in the near future.
Fans who are attending must remember to bring a face mask and their print-at-home match ticket, or else they will be refused entry.
The first edition of Valley Review for the new season is now available to purchase online for delivery straight to your door. Click here for more information on how to get your copy.
Supporters can follow all the build-up to the game on Charlton's official Instagram account, official Twitter account and Facebook page as usual.
Supporters will be able to watch Charlton league games this season live on Valley Pass. All league games, except those selected for UK or international broadcast, will be available to purchase with a match pass which costs £10 in the UK and Ireland and £7 internationally – pricing is set by the EFL.
Supporters living abroad can purchase a season live video pass for £140, which will give them access to every game the club is allowed to stream internationally during the 2020/21 season.
Meanwhile, live audio commentary of the game from Terry Smith and Greg Stubley will be available to Valley Pass subscribers in all countries as usual.